Name: High Protein Spinach Artichoke Chicken Casserole
Prep time: 20 min
Cook time: 30 min
Total time: 50 min
Cuisine: American
Ingredients: Cottage Cheese (16 oz, 4% preferred); Garlic (2 cloves, peeled); Kosher Salt (1/2 tsp + to taste); Black Pepper (1/4 tsp + to taste); Onion Powder (1/4 tsp); Avocado Oil or Olive Oil (1 tsp); Boneless, Skinless Chicken Breast (1 lb, cut into bite-sized pieces); Low Moisture, Part Skim, Finely Shredded Mozzarella Cheese (1/2 cup); Finely Grated Parmesan Cheese (2/3 cup); Artichoke Hearts (1 can, 16 oz, drained); Frozen Chopped Spinach (6 oz, thawed)

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Last updated on January 14, 2026

In the world of comfort food, few dishes evoke a sense of warmth and satisfaction quite like a hearty casserole, especially one that elevates classic flavors into something extraordinary. Picture a beautifully golden-baked casserole, enticing aromas wafting through the air, each bite a creamy celebration of spinach and artichoke paired perfectly with tender chicken. It’s all too easy to shy away from such indulgence, believing it to be a task reserved for seasoned chefs or lavish dinner parties. But rest assured, this High Protein Spinach Artichoke Chicken Casserole invites you to create a culinary masterpiece in your own kitchen, delivering gourmet results without the complexity.

A Quick Look at This High Protein Spinach Artichoke Chicken Casserole Recipe

This High Protein Spinach Artichoke Chicken Casserole is an exquisite blend of flavors and textures that will elevate your dinner game. With the creamy richness of cottage cheese and the heartiness of boneless chicken, it stands as a wholesome dish that doesn’t compromise on taste. The star ingredients, artichokes and spinach, provide a subtle yet vibrant flavor, while the blend of mozzarella and parmesan adds an irresistible topping that melts beautifully in the oven. This recipe is not just about feeding the body but also about nourishing the soul, making it a special yet accessible choice for home cooks eager to impress their family or guests. Who wouldn’t be intrigued by a dish that promises both indulgence and high protein goodness?

Ingredients You’ll Need for High Protein Spinach Artichoke Chicken Casserole

Essentials

Cottage Cheese (16 oz, 4% preferred): Choose a creamy version for a rich, luscious texture. This ingredient acts as the base of your casserole, introducing protein and moisture that elevates the entire dish.
Garlic (2 cloves, peeled): Fresh garlic imparts a fragrant depth that enhances the overall flavor profile, making it fragrant and inviting.
Kosher Salt (1/2 tsp + to taste): A crucial seasoning that balances flavors and enhances each ingredient’s natural taste.
Black Pepper (1/4 tsp + to taste): Freshly cracked black pepper adds a hint of warmth and sophistication.
Onion Powder (1/4 tsp): Provides subtle sweetness and depth, harmonizing beautifully with the garlic.
Avocado Oil or Olive Oil (1 tsp): A high-quality oil contributes healthy fats and a light flavor, perfect for sautéing.
Boneless, Skinless Chicken Breast (1 lb, cut into bite-sized pieces): Lean protein that soaks up the flavors of the casserole while remaining tender and juicy.
Low Moisture, Part Skim, Finely Shredded Mozzarella Cheese (1/2 cup): Melts to a gooey perfection, adding creaminess and rich flavor.
Finely Grated Parmesan Cheese (2/3 cup): Offers a sharp, nutty flavor that complements the other cheeses and rounds out the dish beautifully.
Artichoke Hearts (1 can, 16 oz, drained): Adds an earthy sweetness and intriguing texture, key to the dish’s identity.
Frozen Chopped Spinach (6 oz, thawed): This nutrient-rich green provides color and an unmistakable flavor, packed with protein and fiber for an added nutritional boost.

Optional Add-ons

Crushed Red Pepper Flakes: For a touch of heat that contrasts with the creamy elements, consider adding a pinch before baking.
Fresh Herbs (such as parsley or basil): These can be sprinkled on top post-baking for a burst of brightness, visually appealing and aromatic.
Sliced Green Onions: Adds a fresh crunch and a pop of color that can elevate the presentation.

Substitutions and Shortcuts

Greek Yogurt for Cottage Cheese: If cottage cheese isn’t available, Greek yogurt can create a similar creamy texture while adding protein.
Rotisserie Chicken: For a quicker option, substitute the uncooked chicken with shredded rotisserie chicken.
Frozen Spinach: If fresh is unavailable, frozen spinach works just as well, ensuring that the dish is accessible regardless of the ingredients at hand.

How to Make High Protein Spinach Artichoke Chicken Casserole Step-by-Step

Begin by preheating your oven to 350°F, setting the stage for a perfectly baked casserole. While the oven warms, season the cubed chicken breast with kosher salt and let it sit for at least 20 minutes. This resting period is crucial, as it allows the salt to penetrate the meat, enhancing its flavor and juiciness.

Next, squeeze out any excess liquid from the artichoke hearts and chopped spinach, ensuring that your casserole isn’t watery. In a large skillet, heat the avocado or olive oil over medium heat. Add the seasoned chicken and cook until it is nearly cooked through; this should take about 8-10 minutes. Remove the chicken from the skillet and set it aside, allowing it to finish cooking in the oven alongside the other ingredients.

In your food processor, combine the cottage cheese, garlic, kosher salt, black pepper, and onion powder. Blend until the mixture is smooth and creamy; this will serve as a delightful, flavorful base for your casserole. In a large mixing bowl, combine the cooked chicken, drained artichoke hearts, thawed spinach, and the cottage cheese mixture. Fold in two-thirds of the mozzarella and parmesan, creating a harmonious blend of ingredients.

Transfer this mixture to a baking dish, spreading it evenly, and cover with foil. Bake in your preheated oven for 20 minutes. This initial baking phase allows the flavors to meld beautifully. After this, remove the foil and top with the remaining mozzarella and parmesan cheese. Bake uncovered for an additional 10 minutes, watching carefully to avoid over-browning. If you’re seeking a beautiful golden crust, broil for a minute or two, ensuring the cheese bubbles enticingly.

Common Mistakes to Avoid

Cooking is often a journey of trial and error, and recognizing potential pitfalls can turn mistakes into learning opportunities. When preparing the High Protein Spinach Artichoke Chicken Casserole, remember that every error is a chance to refine your craft and elevate your results.

Mistake 1: Neglecting to Season Properly

Many home cooks underseason their dishes out of hesitation. Remember, seasoning is essential, especially with lean proteins like chicken. A generous pinch of kosher salt at each step ensures the flavors develop beautifully.

Mistake 2: Skipping the Moisture Removal Step

Failing to thoroughly drain your artichokes and spinach can lead to a soggy casserole. It’s vital to squeeze out excess moisture to maintain the casserole’s creamy consistency without excess liquid.

Mistake 3: Overbaking the Chicken

Overcooked chicken can become dry and chewy. Since the chicken will continue to cook in the oven, aim for it to be just underdone while cooking in the skillet. It will finish cooking beautifully in the casserole.

Serving Suggestions for High Protein Spinach Artichoke Chicken Casserole

The beauty of the High Protein Spinach Artichoke Chicken Casserole lies not only in its delectable flavors but also in its versatility in terms of presentation and accompaniments. As it comes out of the oven, the inviting aroma is an invitation to showcase it elegantly at your dining table.

Pair with a Fresh Green Salad

Serve alongside a crisp, fresh salad tossed with a light vinaigrette. The crunch of fresh greens enhances the creamy casserole, creating a perfect balance of flavors and textures on the plate.

Add a Side of Quinoa or Brown Rice

For a more substantial meal, consider pairing your casserole with fluffy quinoa or nutty brown rice. These whole grains are not only nutritious but also complement the creamy cheese and tender chicken beautifully.

FAQs About High Protein Spinach Artichoke Chicken Casserole

1. Can I make the High Protein Spinach Artichoke Chicken Casserole ahead of time?

Absolutely! This casserole can be assembled a day in advance and stored in the refrigerator until you’re ready to bake it. Just add an extra few minutes to the baking time if it has been chilled.

2. Is the High Protein Spinach Artichoke Chicken Casserole suitable for meal prep?

Yes, this dish is perfect for meal preppers. It stores well in the refrigerator for up to four days and reheats beautifully in the microwave or oven.

3. How do I store leftovers of the High Protein Spinach Artichoke Chicken Casserole?

Once cooled, cover the casserole tightly with foil or transfer it to an airtight container. Store it in the fridge for up to four days or freeze for up to three months.

4. Can I substitute other vegetables in the High Protein Spinach Artichoke Chicken Casserole?

Certainly! Feel free to add or substitute vegetables like kale, broccoli, or bell peppers to suit your preferences and elevate the dish’s nutrition.

5. How can I make the High Protein Spinach Artichoke Chicken Casserole gluten-free?

This casserole is inherently gluten-free. Just make sure to use gluten-free substitutes for any ingredients that may contain gluten, such as ensuring your seasoning blends are certified gluten-free.

High Protein Spinach Artichoke Chicken Casserole

A Quick Look at This High Protein Spinach Artichoke Chicken Casserole Recipe